In its third Brazil edition, Executive Forecast continues its in-depth exploration of Brazil's life sciences sector, engaging with key representatives to outline a forward-looking agenda focused on healthcare, patient well-being, and sustainable systems. As the largest economy in Latin America, Brazil is leading innovation and self-reliance efforts, exemplified by initiatives like the Plano Nova Indústria Brasil and Health Minister Nísia Trindade Lima’s leadership of the WHO TB Vaccine Accelerator Council. This report brings together diverse voices from public, private, and multilateral stakeholders to capture Brazil’s dynamic healthcare ecosystem in transition. Through conversations with leaders in pharmaceuticals, MedTech, and healthcare, as well as policymakers and key opinion leaders, we explore how Brazil is working to revitalize domestic production, boost innovation, and ensure health and economic prosperity grow together. Supported by data from IQVIA, WHO/PAHO, and the OECD, this edition highlights Brazil’s path toward becoming a resilient, innovative leader in global healthcare.